See
this post on how to calculate the variance of a wager ik
In short it's:
σ2k = (dk - Ek - 1) * (Ek + 1) * B2k
where σ2k is the variance on the kth bet,
dk is the decimal odds on the kth bet,
Ek is the percent edge of the kth, and
Bk is the size of the kth bet.
To calculate the total variance of N independent bets you'd just sum the individual variances of each separate bet.
σ2TOTAL = ΣNi=1 { (di - Ei - 1) * (Ei + 1) * B2i }
Taking the square root would then give you the standard deviation
Then to determine the p-value in Excel using the CLT you'd just take:
p-value = 1-NORMSDIST((Total Realized $ Return - Σ{Bi * Ei})/σTOTAL)
In other words, the CLT is allowing you to assume that the random variable (Realized Return - Expected Return) / (Standard Dev) is normally distributed with a mean of zero and standard deviation of 1. This assumption becomes increasingly more accurate as number of bets increases. With a smaller sample the t-distribution is probably a better approximation.