Bottom line is that the pre-game moneyline bet will most often be a -EV bet. So, in order for the combo platter to be profitable in the long run, the in-running bet will not only have to have +EV, but even more +EV to compensate for the -EV of the pre-game bet.
....and if you're that good at picking off the in-running stuff, then you're better off doing that exclusively. Good luck.
